TOPCAT METROLOGY SKIN
No skin damage was evident immediately after testing and mild hyperaemia in three cats at 2-3 days resolved rapidly. With probe 3 in cats, after opioid treatment, thermal threshold reached cut-out (55℃) on 24 occasions, exceeded 50℃ in a further 32 tests and exceeded 48℃ in the remainder. Gravel Head Farm Downham Common, Little Downham, Ely, Cambridgeshire, CB6 2TY. The product range today now includes mechanical threshold testers, remote-controlled systems (allowing completely free-ranging subjects during a test) and. for TOPCAT METROLOGY LIMITED (06547084) Registered office address. The company's original product, developed twelve years ago, was a thermal threshold testing system. WMT2) was first developed in horses to replace the wired system by modifying the manually operated. Topcat Metrology develops and supplies novel measurement equipment for veterinary research. Probe 3 produced even heating without blistering in humans. The remote controlled device (Topcat Metrology Ltd. Probe 2 was unwieldy and was not evaluated further. Probe 1b caused less damage than no cooling (27 ± 13 and 38 ± 11 mm(2) respectively, P = 0.0266 median SDS 1.5 and 4 respectively, P = 0.0317) but was cumbersome.
Probe 1a cooled the skin but required further heat dissipation, excessive power, was not 'fail-safe' and was inappropriate for animal mounting.
TOPCAT METROLOGY MANUAL
Human skin was heated to 48℃ (6℃ above threshold) and the resulting burn was evaluated using area of injury and a simple descriptive scale (SDS). Metrology Lab Manual - DEPARTMENT OF MECHANICAL ENGINEERING This preview shows page 1 - 5 out of 33 pages. Probe 3 (developed in the light of evidence of 'hot spots' in probe 0) incorporated reduced thermal mass and even heating across the skin contact area. Probe 2 released skin contact immediately after threshold. Probe 1 incorporated rapid cooling after threshold was reached: probe 1a used a Peltier system and probe 1b used water cooling. Unmodified probe 0 was tested on two humans and promising modifications were also evaluated on cats. Studies were conducted on two humans and eight cats. Thermal probe modifications hypothesized to reduce burning were evaluated for practicality and effect. does not have any related entities listed in the PlainSite database. Corporate Family (0) Topcat Metrology Ltd. The stimulus may cause burning and merits prevention. has not been involved in any trademark assignment transactions in the PlainSite database. Overview of Contact Details, Company Description and Event.
TOPCAT METROLOGY FREE
In animals, however, the sensation experienced is unknown and we assume that a stimulus that is painful to us and which produces an appropriate response in the animal is the threshold for pain.Thermal threshold testing is commonly used for pain research. Free financial and Director check using Companies House information. A similar approach is used in basic research where the mechanical threshold is commonly used in rodents to determine the presence or absence of pain and its exacerbation or alleviation. Studies in human subjects enable the distinction between a whole range of painful and non-painful sensations to be made. In these studies the animal’s aversive response is taken as the endpoint and called the threshold. Analgesics now generally require testing for efficacy, dose and comparison against a gold standard under laboratory conditions prior to drug registration. It is widely used in animal studies to evaluate treatments which either increase the threshold (analgesics) or which decrease it (irritants, trauma, disease). Consultant in Veterinary Anaesthesia and director of Topcat Metrology Ltd. Mechanical nociceptive threshold (MNT) testing is used for both research and the clinical evaluation of pain.
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